Well, I dated your big sister
And took her to a show
I went for some candy
Along came Jim Dandy
And they snuck right out of the door

Ev'ry time I see your sister
Well she's got somebody new
She's mean and she's evil
Like that old Boll Weevil
Guess I'll try my luck with you

Well, I used to pull your pigtails
And pinch your turned-up nose
But you been a growin'
And baby, it's been showin'
From your head down to your toes

Little sister, don't you
Little sister, don't you
Little sister, don't you kiss me once or twice
Then say it's very nice
And then you run

Little sister, don't you
Do what your big sister done

RCA 47-7908, 1961, His Latest Flame / Little Sister

RCA’s Studio B, Nashville, June 26, 1961

Doc Pomus and Mort Shuman wrote Little Sister for Elvis, who recorded it on June 26, 1961, at RCA's Nashville studios. His single release spent a total of 13 weeks on Billboard's Hot 100 chart, reaching #5. Sales exceeded one million copies. In England, Little Sister was number one for four weeks. A few months after Little Sister was released, LaVern Baker recorded Hey, Memphis (Atlantic 2119) as a takeoff on Elvis's recording. Hey, Memphis, which used the same music as Little Sister, was also written by Doc Pomus and Mort Shuman. Elvis occasionally sang Little Sister in concert in a medley with Get Back.

A rehearsal of Little Sister at MGM Culver City studios in July 1970 was used in the documentary Elvis - That's the Way It Is.

In 1988 Dwight Yoakam's music video of Little Sister was nominated for Top Country Video at the Country Music Association Awards.